Summary #952

Protein called REST could prolong life by limiting neuron excitement

quantamagazine.org
  • Overexcited neurons lead to premature death, but a protein called REST appears to be the key to limiting the activity of neurons in the brain.
  • New study shows that people who live the longest have the most REST in their brains, but it’s unclear how exactly it prolongs their lives.
  • Earlier studies showed that people with neurodegenerative diseases like Alzheimer’s have low levels of REST.
  • The next steps are to find drugs that could boost REST, test them in lab organisms, and then test them in patients.

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