Summary #1194

In Situ Expansion, Differentiation, and Electromechanical Coupling of Human Cardiac Muscle in a 3D Bioprinted, Chambered Organoid

ahajournals.org
  • New bioink allows scientists to 3D-print a human heart with - for the first time - cardiac muscles that can pump.
  • It’s a huge step towards printing hearts to replace animal models in transplants, it can also be used for testing cardiac medical devices.
  • In order to achieve this, study authors had to find a way to achieve the right density of cardiomyocytes, which are notoriously hard to grow.
  • They did it by adding pluripotent (=able to grow into different cells) stem cells into the printed structure first, and turning them into cardiomyocytes inside the printed heart.

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