Summary #1190

How to precisely edit mitochondrial DNA

phys.org
  • New method allows scientists to edit genes in mitochondria, the little energy factories inside cells, which was impossible until now, even with CRISPR.
  • It will make it easier to study rare diseases caused by mitochondrial mutations, making it possible to fix certain mitochondrial genes without destroying others.
  • One team identified a protein that worked on double-stranded DNA, another team found a way to insert it into the mitochondria, and a third team verified the results.
  • By splitting the protein in half, inserting it into the mitochondria and reassembling it there, they are able to modify genes without destroying the mitochondria.
  • Now they want to find more proteins that will modify other genes - it’s a huge step for the field of gene editing, but it’s still a long way from being useful in medicine.

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