Summary #1146

Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybin
  • The way we react to psilocybin seems to be connected to the glutamate system (the neuronal fast-signaling system in our brain that uses the glutamate neurotransmitter).
  • Analysis of data collected from 48 participants (26 in the placebo group) links positive experiences of ego dissolution to low levels of glutamate in the hippocampus.
  • Negative ego dissolution and increased feelings of anxiety were linked to higher levels of glutamate in the mFPC (medial prefrontal cortex).
  • All of this means that psilocybin directly influences the glutamate system, and those changes correspond with changes in behaviour during the psychedelic state.
  • These findings go beyond our neuroscientific knowledge, but they still form a necessary foundation for future clinical trials of psilocybin’s therapeutic effects.


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