Me, myself, bye: regional alterations in glutamate and the experience of ego dissolution with psilocybinnature.com
- The way we react to psilocybin seems to be connected to the glutamate system (the neuronal fast-signaling system in our brain that uses the glutamate neurotransmitter).
- Analysis of data collected from 48 participants (26 in the placebo group) links positive experiences of ego dissolution to low levels of glutamate in the hippocampus.
- Negative ego dissolution and increased feelings of anxiety were linked to higher levels of glutamate in the mFPC (medial prefrontal cortex).
- All of this means that psilocybin directly influences the glutamate system, and those changes correspond with changes in behaviour during the psychedelic state.
- These findings go beyond our neuroscientific knowledge, but they still form a necessary foundation for future clinical trials of psilocybin’s therapeutic effects.